中文名称英文名称CAS 编号规格所属品牌订货号
利奈唑酮Linezolid165800-03-325MGSIGMAPZ0014
利奈唑酮Linezolid165800-03-3100MGSIGMAPZ0014
利奈唑酮Linezolid165800-03-31GSIGMAPZ0014
利奈唑酮Linezolid165800-03-35GSIGMAPZ0014
品牌SIGMA
产品名称 利奈唑酮 : Linezolid ——【产品编号:SIGMA-PZ0014】
CAS编号165800-03-3
别名PNU-100766 U-100766,雷奈佐利,吗啉恶酮,利奈唑烷
级别科学级
纯度&分析≥98% (HPLC)
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分子式C16H20FN3O4
分子量337.35
储存条件常温避光保存。
性质

利奈唑胺为抗生素,为细菌蛋白质合成抑制剂,是全合成的恶唑烷酮类抗生素。利奈唑胺对甲氧西林敏感或耐药葡萄球菌、万古霉素敏感或耐药肠球菌、青霉素敏感或耐肺炎链球菌均显示了良好的抗菌作用,对厌氧菌亦具抗菌活性。
利奈唑胺的作用部位和方式独特,因此在具有本质性或获得性耐药特征的阳性细菌中,都不易与其他抑制蛋白合成的抗菌药发生交叉耐药,在体外也不易诱导细菌耐药性的产生。用于耐万古霉素粪肠球菌感染、并发性和非并发性皮肤与皮肤结构感染。

InChI Key   TYZROVQLWOKYKF-ZDUSSCGKSA-N
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >20 mg/mL
originator   Pfizer
storage temp.   room temp

原产地美国
描述

Other Notes
This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information
Sold for research purposes under agreement from Pfizer Inc.


法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


Application
Linezolid has been used in checkerboard-type drug combination MIC (minimum inhibitory concentrations) assay to determine whether ivacaftor shows positive interaction with linezolid.[1] It has been used for the determination of minimum biofilm inhibitory concentration and for the treatment of Mycobacterium abscessus-infected Drosophila melanogaster w1118 flies.[2]
Biochem/physiol Actions
Linezolid is an oxazolidinone antimicrobial. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
General description
Linezolid is the first member of the oxazolidinones antibiotic class which shows wide activity against Gram-positive bacteria, including drug resistant strains.

供货状态True
参考文献N/A
类型抗生素
安全信息

符号  GHS08  GHS08
信号词  Danger
危害声明  H372
警示性声明  P314
靶器官  Bone
RIDADR  NONH for all modes of transport
WGK德国  3
RTECS  AC2720000