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中文名称英文名称CAS 编号规格目录价所属品牌订货号
衣霉素Tunicamycin from Streptomyces sp.11089-65-91MG¥775.00SIGMAT7765
衣霉素Tunicamycin from Streptomyces sp.11089-65-95X1MG¥3,500.00SIGMAT7765
衣霉素Tunicamycin from Streptomyces sp.11089-65-910MG¥6,600.00SIGMAT7765
品牌SIGMA
产品名称 衣霉素 : Tunicamycin from Streptomyces sp. ——【产品编号:SIGMA-T7765】
CAS编号11089-65-9
别名和衣霉素,依霉素
级别科学级
纯度&分析PREMIUM
Tips来源于链霉菌属,是一种常用的研究级抗生素类制品。
分子式N/A
分子量N/A
储存条件2-8 °C 冷藏保存。
性质
Related Categories AIDS and Viral Research Reagents, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Antiviral, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Activators and Inhibitors of ER Stress, Chemical Structure Class, Endoplasmic Reticulum Stress, Glycobiology, Immune Cell Signaling and Blood, Immune System Regulation, Inhibitors, Inhibitors and Substrates, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Nucleosides, Post-Translational Modification, Proteomics, Spectrum of Activity, T
Quality Level   PREMIUM
storage temp.   2-8°C
原产地美国
描述

Biochem/physiol Actions

Antibacterial and antifungal. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates.

General description

Contains homologues A,B,C, and D. Composition may vary from lot to lot. Actual content given on label.

供货状态True
参考文献

Duksin, D. and Mahoney, W.C., Relationship of the structure and biological activity of the natural homologues of tunicamycin. J. Biol. Chem. 257, 3105-3109, (1982)

Mahoney, W.C. and Duksin, D, Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography. J. Chromatogr. Sci. 198, 506-510, (1980)

Matthies H. Jr, Kretlow J., Matthies H., Smalla K.H., Staak S., Krug M., Glycosylation of proteins during a critical time window is necessary for the maintenance of long-term potentiation in the hippocampal CA1 region. Neuroscience 91, 175-183, (1999)

Yunovitz H., Gross K.C., Effect of tunicamycin on metabolism of unconjugated N-glycans in relation to regulation of tomato fruit ripening. Phytochemistry 37, 663-668, (1994)

Nishizaki ,T., Tunicamycin alters channel gating characteristics of junctional and extrajunctional acetylcholine receptors expressed in Xenopus oocytes. Neuroscience 170, 273, (1994)

Lauer, M.E., et al., Primary Murine Airway Smooth Muscle Cells Exposed To Poly(I,C) Or Tunicamycin Synthesize A Leukocyte-adhesive Hyaluronan Matrix. J. Thorac. Cardiovasc. Surg. 284, 5299-312, (2009)

Unal, E.S., et al., The Functional Roles Of The His247 And His281 Residues In Folate And Proton Translocation Mediated By The Human Proton-coupled Folate Transporter SLC46A1. J. Thorac. Cardiovasc. Surg. 284, 17846-57, (2009)

Lauer, M.E., et al., Airway Smooth Muscle Cells Synthesize Hyaluronan Cable Structures Independent Of Inter-alpha-inhibitor Heavy Chain Attachment. J. Thorac. Cardiovasc. Surg. 284, 5313-23, (2009)

Li, B., et al., Orally Administered Particulate β-Glucan Modulates Tumor-Capturing Dendritic Cells And Improves Antitumor T-Cell Responses In Cancer Clin. Cancer Res. 16, 5153-5164, (2010)

Merck 14,9819

类型抗生素
安全信息
符号  GHS06
信号词  Danger
危险声明  H300
警示性声明  P264-P301 + P310
个人防护装备  Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码  T+
风险声明  28
安全声明  28-37/39-45
RIDADR  UN 3462 6.1/PG 2
WGK德国  3
RTECS  YO7980200