| 品牌 |  |
| 产品名称 |
青霉素 G 钠盐 ： Penicillin G sodium salt ——【产品编号：SIGMA-PENNA】
|
| CAS编号 | 69-57-8 |
| 别名 | 青霉素G钠盐，青霉素钠盐，苄基青霉素钠盐，苄青霉素钠盐，Benzylpenicillin sodium salt |
| 级别 | 科学级 |
| 纯度&分析 | ~1650 U/mg |
| Tips | 一种常用的研究级抗生素类制品，可抑制细菌细胞壁合成。 |
| 分子式 |
C16H17N2NaO4S
|
| 分子量 | 356.37 |
| 储存条件 | 常温避光保存。 |
| 性质 |
|
Appearance (Color) |
White to Off-White |
|
Appearance (Form) |
Powder |
|
Solubility (Color) |
Colorless to Faint Yellow |
|
Solubility (Turbidity) |
Clear |
|
|
100 mg/mL, H2O |
|
Infrared spectrum |
Conforms to Structure |
|
Moisture Content |
≤1.5 % |
|
Potency |
1645 - 1675 |
|
|
units Penicillin-G base/mg of solid |
|
| 原产地 | 美国 |
| 描述 |
Biochem/physiol Actions
Mode of Action: Inhibits bacterial cell wall synthesis.
Antimicrobial spectrum: Gram-positive bacteria.
Penicillin G is active against gram-positive and gram-negative aerobic and anaerobic bacteria. Penicillin G inhibits cell wall synthesis by binding to penicillin binding proteins (PBPs), which inhibits peptidoglycan chain cross-linking. Penicillin G is stable against hydrolysis by β-lactamases, such as penicillinases and cephalosporinases.
Application
Penicillin G is narrow spectrum antibiotic. It is the drug of choice for Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Penicillin G sodium salt is used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility 1. It is used in cell culture alone as well as in combination with streptomcyin and other antibiotics2.
|
| 供货状态 | True |
| 参考文献 |
1. P Giesbrecht, T Kersten, et al., Fan-shaped ejections of regularly arranged murosomes involved in penicillin-induced death of Staphylococci. J. Bacteriol. 174, 2241-2252, (1992)
2. P Salanitro, P A Muirhead, et al., Morphological and physiological characteristics of Gemmiger formicilis isolated from chicken ceca. Appl. Environ. Microbiol. 32, 623-632, (1976)
Martin, H.H. and Gmeiner, J., Modification of peptidoglycan structure by penicillin action in cell walls of Proteus mirabilis. Eur. J. Biochem. 95, 487, (1979)
Merck 14,7094
Beil. 27,IV,5861
|
| 类型 | 抗生素 |
| 安全信息 |
|
符号 |
 |
|
信号词 |
Danger |
|
危险声明 |
H317-H334 |
|
警示性声明 |
P261-P280-P342 + P311 |
|
个人防护装备 |
dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|
危害码 |
Xn |
|
风险声明 |
42/43 |
|
安全声明 |
22-36/37-45 |
|
WGK德国 |
2 |
|
RTECS |
XH9800000 |
|