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中文名称英文名称CAS 编号规格目录价所属品牌订货号
α-酪蛋白α-Casein from bovine milk9000-71-9250MG¥646.00SIGMAC6780
α-酪蛋白α-Casein from bovine milk9000-71-91G¥1,875.00SIGMAC6780
α-酪蛋白α-Casein from bovine milk9000-71-95G¥7,522.00SIGMAC6780
α-酪蛋白α-Casein from bovine milk9000-71-910G¥11,206.00SIGMAC6780
品牌SIGMA
产品名称 α-酪蛋白 : α-Casein from bovine milk ——【产品编号:SIGMA-C6780】
CAS编号9000-71-9
别名N/A
级别生化级
纯度&分析≥70% αs-casein basis (electrophoresis), lyophilized powder
Tips源自新鲜牛奶。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质
assay ≥70% αs-casein basis (electrophoresis)
form lyophilized powder
storage temp. −20°C
原产地美国
描述

Preparation Note

Chromatographically purified

Application

α-Casein from bovine milk is an Immunoglobulin E (IgE)-binding epitope belonging to the Casein phosphoprotein family. It has been used in studies of children with insulin-dependent diabetes mellitus (IDDM), due to the strong cross-reactivity of α-casein antibodies with insulin. Studies of children displaying (IDDM) show higher levels of α-casein antibodies than control siblings, which may serve as a risk marker for IDDM.

Biochem/physiol Actions

α-Casein can be an immunogen in young children, and anti-a-casein antibodies have strong cross-reactivity with insulin. This effect can explain the uncommon insulin autoimmunity, but it does not appear to progress to Type I diabetes.1

供货状态True
参考文献

1. Adler, K., et al., Insulin autoantibodies with high affinity to the bovine milk protein alpha casein Clin. Exp. Immunol. 164, 42-49, (2011)

Karuso, P., et al., Real-time fluorescence monitoring of tryptic digestion in proteomics. J. Proteome Res. 7, 361-6, (2008)

Saukkonen T., et al, Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype. Childhood Diabetes in Finland Study Group. Diabetologia 41, 72-78, (1998)

Adler K., et al., Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Clin. Exp. Immunol. 164, 42-49, (2011)

Merck 14,1883

类型培养基
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3