中文名称英文名称CAS 编号规格所属品牌订货号
放线菌酮Cycloheximide66-81-9100MGSIGMAC7698
放线菌酮Cycloheximide66-81-91GSIGMAC7698
放线菌酮Cycloheximide66-81-95GSIGMAC7698
放线菌酮Cycloheximide66-81-925GSIGMAC7698
品牌SIGMA
产品名称 放线菌酮 : Cycloheximide ——【产品编号:SIGMA-C7698】
CAS编号66-81-9
别名3-[2-(3,5-二甲基-2-氧代环己基)-2-羟乙基]戊二酰亚胺,奈良霉素 A,戊二酰亚胺环己酮,环己酰亚胺,放线酮,戊二酰亚胺环己酮,亚胺环己酮,actidione
级别分子生物级
纯度&分析from microbial, ≥94% (TLC)
Tips一种常用的研究级抗生素类制品,适用于科学研究、辅料、规模化生产等。
分子式C15H23NO4
分子量281.35
储存条件2-8 °C 冷藏保存。
性质
APPEARANCE WHITE TO OFF-WHITE POWDER
SOLUBILITY CLEAR TO HAZY COLORLESS TO LIGHT YELLOW SOLUTION AT 50MG/ML IN ETHANOL
IR SPECTRUM CONFORMS TO STRUCTURE
ELEMENTAL ANALYSIS 63.5 TO 64.5% CARBON
  4.7 TO 5.3% NITROGEN
PURITY BY THIN LAYER CHROMATOGRAPHY > OR = 94%
原产地美国
描述

Biochem/physiol Actions

放线菌酮 (CHX) 是由灰色链霉菌产生的抗生素。它的主要生物活性为真核生物中的翻译抑制,从而导致细胞生长停滞和细胞死亡。CHX 广泛用于选择酵母菌和真菌 CHX 耐药株,可控抑制蛋白合成以检测短寿命蛋白和超高诱导蛋白表达,以及进行凋亡诱导或通过死亡受体促进凋亡诱导。

供货状态True
参考文献

Obrig, T.G., et al. J. Biol. Chem. 246, 174, (1971)

Sheth, U., et al., Perinuclear P Granules Are The Principal Sites Of MRNA Export In Adult C. Elegans Germ Cells. Development 137, 1305-14, (2010)

Patterson, S.T., and Reithmeier, R.A., Cell Surface Rescue Of Kidney Anion Exchanger 1 Mutants By Disruption Of Chaperone Interactions. J. Thorac. Cardiovasc. Surg. 285, 33423-34, (2010)

Cheshenko, N., et al., HSV Usurps Eukaryotic Initiation Factor 3 Subunit M For Viral Protein Translation: Novel Prevention Target. PLoS ONE 5, e11829, (2010)

Marongiu, M., et al., The Forkhead Transcription Factor Foxl2 Is Sumoylated In Both Human And Mouse: Sumoylation Affects Its Stability, Localization, And Activity. PLoS ONE 5, e9477, (2010)

Harris, E.S., and Nelson, W.J., Adenomatous Polyposis Coli Regulates Endothelial Cell Migration Independent Of Roles In Beta-catenin Signaling And Cell-cell Adhesion. Molecular Biology of the Cell 21, 2611-23, (2010)

Clancy, E.K., and Duncan, R., Helix-Destabilizing, {beta}-Branched, And Polar Residues In The Baboon Reovirus P15 Transmembrane Domain Influence The Modularity Of FAST Proteins. J. Virol. 85, 4707-19, (2011)

Clancy, E., et al., Helix-Destabilizing, β-Branched, And Polar Residues In The Baboon Reovirus P15 Transmembrane Domain Influence The Modularity Of FAST Proteins J. Virol. 85, 4707-4719, (2011)

Merck 14,2728

Beil. 21,V,13,434

类型抗生素
安全信息
符号 GHS06GHS08GHS09
信号词 Danger
危险声明 H300-H341-H360D-H411
警示性声明 P201-P264-P273-P281-P301 + P310-P308 + P313
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T+,N
风险声明 61-28-51/53-68
安全声明 53-45-61
RIDADR UN 2811 6.1/PG 1
WGK德国 3
RTECS MA4375000