| 品牌 |  |
| 产品名称 |
塞来昔布 ： Celecoxib ——【产品编号：SIGMA-PZ0008】
|
| CAS编号 | 169590-42-5 |
| 别名 | 塞内昔布，噻利考西，4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide，CJ-016377，CP-598107，PF-00345549，PHA-00846533，SC-58635，YM-177 |
| 级别 | 科学级 |
| 纯度&分析 | ≥98% (HPLC) |
| Tips | 一种常用的化学原料药，用于科研、辅料、规模化生产等。 |
| 分子式 |
C17H14F3N3O2S
|
| 分子量 | 381.37 |
| 储存条件 | 常温避光保存。 |
| 性质 |
|
assay |
≥98% (HPLC) |
|
form |
powder |
|
color |
white to off-white |
|
solubility |
DMSO: >20 mg/mL |
|
storage temp. |
room temp |
|
| 原产地 | 美国 |
| 描述 |
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Celecoxib is a non-steroidal, anti-inflammatory drug (NSAID) and a cyclooxygenase-2 (COX-2) selective inhibitor. Celecoxib is at least 10-20 times more selective for COX-2 over COX-1.
|
| 供货状态 | True |
| 参考文献 |
Arsenic Trioxide Inhibits Invasion/migration In SGC-7901 Cells By Activating The Reactive Oxygen Species-dependent Cyclooxygenase-2/matrix Metalloproteinase-2 Pathway. Liu, Y., et al. Exp. Biol. Med. 236, 592-7, (2011)
Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles. Brueggemann LI., et al. Mol. Pharmacol. 76, 1053-1061, (2009)
Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor. Tang C., et al. J. Pharmacol. Exp. Ther. 293, 453-459, (2000)
The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity. Tacconelli S., et al. Curr. Med. Res. Opin. 18, 503-511, (2002)
Merck 14,1956
|
| 类型 | BSZH 生物化学研究 |
| 安全信息 |
|
符号 |
 |
|
信号词 |
Danger |
|
危险声明 |
H360 |
|
警示性声明 |
P201-P308 + P313 |
|
危害码 (欧洲) |
Xn |
|
风险声明 (欧洲) |
60-61-52 |
|
安全声明 (欧洲) |
22 |
|
WGK德国 |
3 |
|
RTECS |
DB2944937 |
|