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中文名称英文名称CAS 编号规格目录价所属品牌订货号
5-氟脲嘧啶5-Fluorouracil51-21-81G¥366.00SIGMAF6627
5-氟脲嘧啶5-Fluorouracil51-21-85G¥1,265.00SIGMAF6627
5-氟脲嘧啶5-Fluorouracil51-21-810G¥2,330.00SIGMAF6627
品牌SIGMA
产品名称 5-氟脲嘧啶 : 5-Fluorouracil ——【产品编号:SIGMA-F6627】
CAS编号51-21-8
别名5-氟尿嘧啶,2,4-二羟基-5-氟嘧啶,5-FU,5-氟-2,4(1H,3H)-嘧啶二酮,2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
级别超纯级
纯度&分析≥99% (HPLC), powder
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分子式

C4H3FN2O2

分子量130.08
储存条件常温避光保存。
性质
Related Categories Antitumor Agents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Research, Cell Biology,
Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cell Signaling and Neuroscience, DNA Synthesis Inhibitors, F, Inhibitors, Other Apoptosis Related Reagents
assay   ≥99% (HPLC)
form   powder
color   white
mp   282-286 °C (dec.)(lit.)
solubility   1 M NH4OH: soluble
  DMSO/DMF: soluble
  methanol: soluble
原产地美国
描述
Biochem/physiol Actions

A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

供货状态True
参考文献
Autophagy in Cancer Promotes Therapeutic Resistance

Autophagy is a highly regulated process by which long-lived proteins, organelles, and protein aggregates are captured within autophagosomes, which are then fused with lysosomes for degradation.1 Auto...
Linda Stephenson, Ph.D., Product Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 9
Keywords: Apoptosis, Autophagy, Cancer, Degradations, Metabolites, transformation

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA. The metabolic pathways supporting nucl...
Keywords: Cancer, Catalysis, DNA replication, Gene expression, Glycolysis, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Pyrimidine synthesis

类型BSZH 生物化学研究
安全信息
符号  GHS06  
信号词  Danger
危险声明  H301-H412
警示性声明  P273-P301 + P310
危害码 (欧洲)  T
风险声明 (欧洲)  25-52
安全声明 (欧洲)  45
RIDADR  UN 2811 6.1 / PGIII
WGK德国  3