| 品牌 |  |
| 产品名称 |
多粘菌素E硫酸盐 ： Colistin sulfate salt ——【产品编号：SIGMA-C4461】
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| CAS编号 | 1264-72-8 |
| 别名 | 硫酸粘杆菌素，Polymyxin E，硫酸多粘菌素E |
| 级别 | 科学级 |
| 纯度&分析 | ≥15,000 U/mg |
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| 分子式 | C53H100O13N16 |
| 分子量 | 2801.27 |
| 储存条件 | 2-8 °C 冷藏保存。 |
| 性质 | 属抗生素类药，本品仅供科研，本品由多粘杆菌产生，对革兰氏阴性菌有较强的抗菌作用，用于治疗革兰氏阴性菌引起的肠道疾病。硫酸粘杆菌素用于，穿透细菌的
性状：白色至类白色或微黄色粉末；无臭或几乎无臭。有引湿性。在水中易溶，在乙醇中微溶，在丙酮、氯仿或乙醚中几乎不溶。
~form powder
solubility H2O: soluble50 mg/mL
Mode of action cell membrane | interferes
antibiotic activity spectrum Gram-negative bacteria
storage temp. 2-8°C
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| 原产地 | 美国 |
| 描述 | Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH [1].
Application
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii [2]. It has been used to study hephrotoxicity in the rat kidney [1], and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa [3].
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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| 供货状态 | True |
| 参考文献 | N/A |
| 类型 | 抗生素 |
| 安全信息 | ~符号 GHS06 GHS06
信号词 Danger
危害声明 H301
警示性声明 Missing Phrase - N15.00950417
个人防护装备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
危害码 (欧洲) T
风险声明 (欧洲) 25
安全声明 (欧洲) 45
RIDADR UN 2811 6.1 / PGIII
WGK德国 3
RTECS TR1500000
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