中文名称英文名称CAS 编号规格所属品牌订货号
利巴韦林Ribavirin36791-04-510MGSIGMAR9644
利巴韦林Ribavirin36791-04-550MGSIGMAR9644
利巴韦林Ribavirin36791-04-51GSIGMAR9644
利巴韦林Ribavirin36791-04-55GSIGMAR9644
品牌SIGMA
产品名称 利巴韦林 : Ribavirin ——【产品编号:SIGMA-R9644】
CAS编号36791-04-5
别名三氨唑核苷,三唑核苷,病毒唑,三氮唑核苷,威乐星
级别科学级
纯度&分析antiviral
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分子式C8H12N4O5
分子量244.20
储存条件2-8 °C 冷藏保存。
性质

性状:粉末,溶于水。熔点174~176℃

用途:生化研究,利巴韦林为广谱抗病毒药。体外具有抑制呼吸道合胞病毒、流感病毒、甲肝病毒、腺病毒等多种病毒生长的作用,其机制不全清楚。本品并不改变病毒吸附、侵入和脱壳,也不诱导干扰素的产生。药物进入被病毒感染的细胞后迅速磷酸化,其产物作为病毒合成酶的竞争性抑制剂,抑制肌苷单磷酸脱氢酶、流感病毒RNA多聚酶和mRNA鸟苷转移酶,从而引起细胞内鸟苷三磷酸的减少,损害病毒RNA和蛋白合成,使病毒的复制与传播受抑。对呼吸道合胞病毒也可能具免疫作用及中和抗体作用。

InChI Key   IWUCXVSUMQZMFG-AFCXAGJDSA-N
antibiotic activity spectrum   viruses
storage temp.   2-8°C

原产地美国
描述

Biochem/physiol Actions
Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.

Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.


General description
Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.


法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC


Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. R9644.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

供货状态True
参考文献N/A
类型抗生素
安全信息

符号  GHS08  GHS08
信号词  Danger
危害声明  H360
警示性声明  P201-P308 + P313
个人防护装备  Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 (欧洲)  T
风险声明 (欧洲)  61
安全声明 (欧洲)  53-22-45
RIDADR  NONH for all modes of transport
WGK德国  3
RTECS  XZ4250000