| 品牌 |  |
| 产品名称 |
盐酸拓扑替康 ： Topotecan hydrochloride hydrate ——【产品编号：SIGMA-T2705】
|
| CAS编号 | 123948-87-8 |
| 别名 | 拓扑替康盐酸盐，NSC-609669 hydrochloride hydrate，SKF-104864A hydrochloride hydrate，hycamptamine hydrochloride hydrate |
| 级别 | 科学级 |
| 纯度&分析 | ≥98% (HPLC and enzymatic) |
| Tips | 此产品是一种拓扑异构酶抑制剂和凋亡诱导剂。是一种强有力的抗肿瘤原料。 |
| 分子式 |
C23H23N3O5 · xHCl · yH2O |
| 分子量 | 421.45 |
| 储存条件 | -20 °C 低温冷冻保存。 |
| 性质 |
|
assay |
≥98% (HPLC and enzymatic) |
|
form |
powder |
|
storage condition |
desiccated |
|
|
protect from light |
|
color |
yellow |
|
solubility |
DMSO: ≥20 mg/mL |
|
storage temp. |
−20°C |
|
| 原产地 | 美国 |
| 描述 |
Biochem/physiol Actions
Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.
|
| 供货状态 | True |
| 参考文献 |
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues. Arun, B., and Frenkel, E.P. Expert Opin. Pharmacother. 2, 491-505, (2001)
Topotecan for the treatment of small-cell lung cancer. Nicum, S.J., and O'Brien, M.E. Expert Rev. Anticancer Ther. 7, 795-801, (2007)
Merck 14,9548
|
| 类型 | BSZH 生物化学研究 |
| 安全信息 |
|
符号 |
 |
|
信号词 |
Warning |
|
危险声明 |
H341 |
|
警示性声明 |
P281 |
|
风险声明 (欧洲) |
46-48 |
|
安全声明 (欧洲) |
22-36 |
|
RIDADR |
UN 2811 6.1/PG 3 |
|
WGK德国 |
3 |
|