品牌 |  |
产品名称 |
盐酸拓扑替康 : Topotecan hydrochloride hydrate ——【产品编号:SIGMA-T2705】
|
CAS编号 | 123948-87-8 |
别名 | 拓扑替康盐酸盐,NSC-609669 hydrochloride hydrate,SKF-104864A hydrochloride hydrate,hycamptamine hydrochloride hydrate |
级别 | 科学级 |
纯度&分析 | ≥98% (HPLC and enzymatic) |
Tips | 此产品是一种拓扑异构酶抑制剂和凋亡诱导剂。是一种强有力的抗肿瘤原料。 |
分子式 |
C23H23N3O5 · xHCl · yH2O |
分子量 | 421.45 |
储存条件 | -20 °C 低温冷冻保存。 |
性质 |
assay |
≥98% (HPLC and enzymatic) |
form |
powder |
storage condition |
desiccated |
|
protect from light |
color |
yellow |
solubility |
DMSO: ≥20 mg/mL |
storage temp. |
−20°C |
|
原产地 | 美国 |
描述 |
Biochem/physiol Actions
Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.
|
供货状态 | True |
参考文献 |
Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues. Arun, B., and Frenkel, E.P. Expert Opin. Pharmacother. 2, 491-505, (2001)
Topotecan for the treatment of small-cell lung cancer. Nicum, S.J., and O'Brien, M.E. Expert Rev. Anticancer Ther. 7, 795-801, (2007)
Merck 14,9548
|
类型 | BSZH 生物化学研究 |
安全信息 |
符号 |
 |
信号词 |
Warning |
危险声明 |
H341 |
警示性声明 |
P281 |
风险声明 (欧洲) |
46-48 |
安全声明 (欧洲) |
22-36 |
RIDADR |
UN 2811 6.1/PG 3 |
WGK德国 |
3 |
|