中文名称英文名称CAS 编号规格所属品牌订货号
坎地沙坦酯Candesartan cilexetil145040-37-510MGSIGMASML0245
坎地沙坦酯Candesartan cilexetil145040-37-550MGSIGMASML0245
坎地沙坦酯Candesartan cilexetil145040-37-51GSIGMASML0245
品牌SIGMA
产品名称 坎地沙坦酯 : Candesartan cilexetil ——【产品编号:SIGMA-SML0245】
CAS编号145040-37-5
别名坎地沙坦西酯,坎地沙坦西来替昔酯,TCV 116,TCY 116
级别科学级
纯度&分析≥98% (HPLC)
Tips一种强有力的血管紧张素II受体拮抗剂。
分子式 C33H34N6O6
分子量610.66
储存条件2-8 °C 冷藏保存。
性质
Related Categories Angiotensin Receptor Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Proteins and Derivatives, Takeda
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: ≥15 mg/mL
storage temp.   2-8°C
原产地美国
描述

Biochem/physiol Actions

Candesartan cilexetil is the prodrug form of the potent angiotensin II receptor antagonist, candesartan. The prodrug is cleaved by esterases within the intestine to liberate the active molecule.

供货状态True
参考文献

CV-11974, the active metabolite of TCV-116 (Candesarten), inhibits the synergistic or additive effect of different growth factors on angiotensin II-induced proliferation of vascular smooth muscle cells. Sachinidis A, el-Haschimi K, Ko Y, Seul C, Düsing R, Vetter H. Biochem. Pharmacol. 1, 123-6, (1996)

Hypotensive activity of TCV-116, a newly developed angiotensin II receptor antagonist, in spontaneously hypertensive rats. Mizuno K, Niimura S, Tani M, Saito I, Sanada H, et al. Life Sci. 20, PL183-7, (1992)

类型BSZH 生物化学研究
安全信息
符号  GHS08GHS09
信号词  Warning
危险声明  H361-H400
警示性声明  P273-P281
危害码 (欧洲)  T,N
风险声明 (欧洲)  61-48/20-50
安全声明 (欧洲)  53-45-61
WGK德国  3