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中文名称英文名称CAS 编号规格目录价所属品牌订货号
肝素钠Heparin sodium salt from porcine intestinal mucosa9041-08-1~1G (180KU)¥1,752.62SIGMA-ALDRICHH3149
肝素钠Heparin sodium salt from porcine intestinal mucosa9041-08-1~2.8G (500KU)¥5,237.91SIGMA-ALDRICHH3149
肝素钠Heparin sodium salt from porcine intestinal mucosa9041-08-1~5.6G (1MU)¥8,453.19SIGMA-ALDRICHH3149
品牌SIGMA-ALDRICH
产品名称 肝素钠 : Heparin sodium salt from porcine intestinal mucosa ——【产品编号:SIGMA-ALDRICH-H3149】
CAS编号9041-08-1
别名肝素,肝素钠盐,Deligoparin sodium,Minolteparin sodium,Nadroparine sodium
级别细胞培养级
纯度&分析Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture
Tips来源于猪肠粘膜,用做抗凝剂,可防止凝血酶原转变成凝血酶。
分子式N/A
分子量N/A
储存条件常温避光保存。
性质
type Grade I-A
product line BioReagent
form powder
solubility H2O: soluble50 mg/mL
suitability suitable for cell culture
原产地美国
描述

Heparin is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is biosynthesized and stored in mast cells of various mammalian tissues, particularly liver, lung and mucosa. Commercial heparin is chiefly isolated from beef lung or pork intestinal mucosa.


Heparin has been used for years as an anticoagulant. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor, accelerating significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin).


The activity of heparin as an anticoagulant has been shown to be related to the molecular weight; in the range of 6-12 kDa, heparin apparently binds to AT-III in a 1:1 stoichiometry. However, porcine heparin of MW 20 kDa can have two binding regions for AT-III, but the probability of a third region is negligible.7,8 There is a correlation between molecular weight and anticoagulant activity, but it is linear only over a narrow range (8-12 kDa).


The action of heparin is clinically monitored using an activated partial thromboplastin time (APTT); these two products are not tested using APTT activity. Low molecular weight heparins (below approximately 8000 Da) inhibit AT-III but have a higher ratio of anti-factor Xa to anti-AT-III activity than regular heparin. They have lowered effect on platelet aggregation than normal heparin, and no significant effect on blood coagulation tests such as APTT. Dosages of these products cannot be equated to those of "normal molecular weight heparin".

供货状态True
参考文献

Merck 14,4653

类型BSZH 生物化学研究
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 2
RTECS MI0850000