| 品牌 |  |
| 产品名称 |
雷帕霉素 ： Rapamycin from Streptomyces hygroscopicus ——【产品编号：SIGMA-R0395】
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| CAS编号 | 53123-88-9 |
| 别名 | 西罗莫司，RPM;RAPA;sirolimus(Sirolimus);RAPAMUNE;Rapamycin/Sirolimus;Rapamycin(Sirolimus)，AY 22989 |
| 级别 | 科学级 |
| 纯度&分析 | ≥95% (HPLC), powder |
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| 分子式 | C51H79NO13 |
| 分子量 | 914.17 |
| 储存条件 | -20 °C 低温冷冻保存。 |
| 性质 | 用途及描述：
科研试剂，广泛应用于分子生物学，药理学等科研方面。雷帕霉素（西罗莫司）是新型大环内酯的抗排斥药物，是目前世界上最新的强效免疫抑制剂。本品抑制由抗原和细胞因子（白介素IL-2、IL-4和IL-15）激发的T淋巴细胞的活化和增殖，它亦抑制抗体的产生。在细胞中，西罗莫司与免疫嗜素，即FK结合蛋白-12（FKBP-12）结合，生成FKBP-12免疫抑制复合物。此复合物与哺乳动物的西罗莫司BA分子（mTOR，一种关键的调节激酶）结合并抑制其活性，从而抑制细胞周期中G1期向S期的发展。
储存条件：-20℃，避光防潮密闭干燥。
~assay ≥95% (HPLC)
form powder
color off-white
solubility ethanol: soluble2 mM
DMSO: soluble
Mode of action enzyme | inhibits
protein synthesis | interferes
antibiotic activity spectrum fungi
yeast
originator Pfizer
storage temp. −20°C
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| 原产地 | 美国 |
| 描述 | Biochem/physiol Actions
A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
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| 供货状态 | True |
| 参考文献 | N/A |
| 类型 | 抗生素 |
| 安全信息 | ~个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK德国 2
RTECS VE6250000
|