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中文名称英文名称CAS 编号规格目录价所属品牌订货号
5-氮杂-2′-脱氧胞苷5-Aza-2′-deoxycytidine2353-33-55MG¥872.00SIGMAA3656
5-氮杂-2′-脱氧胞苷5-Aza-2′-deoxycytidine2353-33-510MG¥1,562.00SIGMAA3656
5-氮杂-2′-脱氧胞苷5-Aza-2′-deoxycytidine2353-33-550MG¥5,765.00SIGMAA3656
5-氮杂-2′-脱氧胞苷5-Aza-2′-deoxycytidine2353-33-51G¥65,770.00SIGMAA3656
品牌SIGMA
产品名称 5-氮杂-2′-脱氧胞苷 : 5-Aza-2′-deoxycytidine ——【产品编号:SIGMA-A3656】
CAS编号2353-33-5
别名5-氮杂-2′-脱氧胞嘧啶核苷,地西他滨,2′-Deoxy-5-azacytidine,4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one,Decitabine
级别科学级
纯度&分析≥97%
Tips一种效果极佳的DNA甲基化特异性抑制剂。
分子式C8H12N4O4
分子量228.21
储存条件常温避光保存。
性质
assay ≥97%
solubility acetic acid: water (1:1): soluble50 mg/mL
原产地美国
描述

General description

Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.

Biochem/physiol Actions

5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.

供货状态True
参考文献

Chiurazzi, P., et al., Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene. Hum. Mol. Genet. 8, 2317-2323, (1999)

Slack, A., et al., Feedback regulation of DNA methyltransferase gene expression by methylation. Eur. J. Biochem. 264, 191-199, (1999)

Chen, R.Z., et al., DNA hypomethylation leads to elevated mutation rates. Nature 395, 89-93, (1998)

Whang, Y.E., et al., Inactivation of the tumor suppressor TEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl. Acad. Sci. U. S. A. 95, 5246-5250, (1998) 摘

Rosenfeld CS., Clinical development of decitabine as a prototype for an epigenetic drug program Semin. Oncol. 32, 465-472, (2005)

Gozzini A, and Santini V., Butyrates and decitabine cooperate to induce histone acetylation and granulocytic maturation of t(8;21) acute myeloid leukemia blasts Ann. Hematol. 84 Suppl 1, 54-60, (2005)

Jowaed, A., et al., Methylation Regulates Alpha-synuclein Expression And Is Decreased In Parkinson's Disease Patients' Brains. J. Neurosci. 30, 6355-9, (2010)

Noguer-Dance, M., et al., The Primate-specific MicroRNA Gene Cluster (C19MC) Is Imprinted In The Placenta. Hum. Mol. Genet. 19, 3566-82, (2010)

Bouzas-Rodriguez, J., et al., Neurotrophin-3 Production Promotes Human Neuroblastoma Cell Survival By Inhibiting TrkC-induced Apoptosis. J. Clin. Invest. 120, 850-8, (2010)

Voutsinas, G.E., et al., Allelic Imbalance Of Expression And Epigenetic Regulation Within The Alpha-synuclein Wild-type And P.Ala53Thr Alleles In Parkinson Disease. Hum. Mutat. 31, 685-91, (2010)

Yang, I., et al., Fused-core Silica Column Ultra-performance Liquid Chromatography-ion Trap Tandem Mass Spectrometry For Determination Of Global DNA Methylation Status. Anal. Biochem. 409, 138-43, (2011)

Merck 14,2853

类型BSZH 生物化学研究
安全信息
符号 GHS07GHS08
信号词 Danger
危险声明 H302-H315-H319-H335-H341-H360
警示性声明 P201-P261-P281-P305 + P351 + P338-P308 + P313
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves
危害码 T
风险声明 61-22-36/37/38-68
安全声明 53-26-36/37
WGK德国 3
RTECS XZ3012000