中文名称英文名称CAS 编号规格所属品牌订货号
土霉素盐酸盐Oxytetracycline hydrochloride2058-46-010GSIGMAO5875
土霉素盐酸盐Oxytetracycline hydrochloride2058-46-050GSIGMAO5875
土霉素盐酸盐Oxytetracycline hydrochloride2058-46-0100GSIGMAO5875
土霉素盐酸盐Oxytetracycline hydrochloride2058-46-01KGSIGMAO5875
品牌SIGMA
产品名称 土霉素盐酸盐 : Oxytetracycline hydrochloride ——【产品编号:SIGMA-O5875】
CAS编号2058-46-0
别名盐酸氧四环素,盐酸地霉素,盐酸土霉素
级别科学级
纯度&分析≥95% (HPLC), crystalline
Tips一种常用的抗生素,靠阻止氨基酰-tRNA结合到30S亚单位上抑制蛋白合成。
分子式 C22H24N2O9 · HCl
分子量496.89
储存条件常温避光保存。
性质
APPEARANCE YELLOW POWDER
SOLUBILITY CLEAR TO SLIGHTLY HAZY YELLOW TO YELLOW-ORANGE SOLUTION AT 200MG PLUS 4.0ML OF WATER:ETHANOL (2:1)
ELEMENTAL ANALYSIS * 50.5 TO 54.5% CARBON
  5.3 TO 5.9% NITROGEN
WATER BY KARL FISCHER < OR = 2%
PURITY BY HPLC > OR = 95%
原产地美国
描述

Application

Oxytetracycline is a tetracycline analog isolated from the actinomycete streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells1 and antibiotic susceptibilities of Mycopasma bovis isolates2. Product O5875 is ≥95% (HPLC), crystalline.

Biochem/physiol Actions

Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

供货状态True
参考文献

1. M Y Wells and Y Rikihisa, Lack of lysosomal fusion with phagosomes containing Ehrlichia risticii in P388D1 cells: abrogation of inhibition with oxytetracycline. Infect. Immun. 56, 3209-3215, (1988)

2. A. Thomas, C. Nicolas, et al., Antibiotic susceptibilities of recent isolates of Mycopasma bovis in Belgium Vet. Rec. 153, 428-431, (2003)

Roberts, M.C., Update on acquired tetracycline resistance genes. FEMS Microbiol. Lett. 245, 195-203, (2005)

Kroon, A.M., et al., The mitochondrial genetic system as a target for chemotherapy: tetracyclines as cytostatics. Cancer Lett. 25, 33-40, (1984)

Aminov, R.I., et al., Detection of tetracycline resistance genes by PCR methods. Methods Mol. Biol., (2004) 268, 3-13

Merck 14,6976

Beil. 14,IV,2630

类型抗生素
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 2
RTECS QI8225000